西班牙Certest艱難梭菌GDH重組蛋白

廣州健侖生物科技有限公司

廣州健侖長期供應(yīng)各種生物原料，主要代理品牌：西班牙Certest。

主要產(chǎn)品包括各種生物單克隆抗原抗體、重組蛋白。

西班牙Certest艱難梭菌GDH重組蛋白

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

歡迎咨詢

歡迎咨詢2042552662

【產(chǎn)品介紹】

西班牙

我們的機(jī)體進(jìn)化出了一些途徑來擺脫有缺陷的干細(xì)胞。來自科羅拉多大學(xué)癌癥中心的研究人員在發(fā)表于《干細(xì)胞》(Stem Cells)雜志上的一項(xiàng)研究中揭示，其中一條途徑就是通過“重編程”使得被輻射損傷的干細(xì)胞分化為不再能夠長久生存的其他細(xì)胞。輻射會(huì)使得干細(xì)胞喪失它的“干性”。這的確有意義：你不會(huì)希望受損的干細(xì)胞繼續(xù)留在這兒生成受損細(xì)胞。
這項(xiàng)研究還證實(shí)，當(dāng)全身遭受輻射時(shí)清除輻射損傷干細(xì)胞的同一“編程”防衛(wèi)機(jī)制導(dǎo)致了血癌生長(延伸閱讀：Sci Rep：福島核輻射后 動(dòng)物血液出現(xiàn)異常 )。通過重編程這一防衛(wèi)機(jī)制，我們或許能夠在全身輻射之后防止癌癥。
論文的資深作者、科羅拉多大學(xué)醫(yī)學(xué)院生物化學(xué)和分子遺傳學(xué)教授、癌癥中心研究員James DeGregori博士說：“機(jī)體并未進(jìn)化至可以應(yīng)對核反應(yīng)堆泄漏及CT掃描。它只能一次處理少數(shù)接受危險(xiǎn)劑量輻射或DNA遭到其他損傷的細(xì)胞。”
DeGregori、博士生Courtney Fleenor及同事們調(diào)查了全身輻射對于小鼠造血干細(xì)胞(HSCs)的影響。在這種情況下，輻射提高了造血干細(xì)胞系統(tǒng)中的細(xì)胞發(fā)生分化的幾率。只是，雖然大多數(shù)細(xì)胞會(huì)遵循這一指令，但有少數(shù)細(xì)胞則不會(huì)。攜帶一種特異突變的干細(xì)胞能夠違抗這一分化指令，保持它們的“干性”。遺傳抑制C/EBPα 可使得少數(shù)干細(xì)胞維持這一能力，繼續(xù)充當(dāng)干細(xì)胞。在與其他細(xì)胞的競爭中，健康干細(xì)胞被清除，C/EBPα 減少的干細(xì)胞在血細(xì)胞生成系統(tǒng)中占據(jù)主導(dǎo)地位。通過這種方式，血液系統(tǒng)從C/EBPα +細(xì)胞轉(zhuǎn)變?yōu)橹饕荂/EBPα -細(xì)胞。
導(dǎo)致C/EBPα 基因受到抑制的一些突變和其他遺傳變異與人類急性髓性白血病有關(guān)聯(lián)。因此，并非是輻射所引起的突變，而是被錯(cuò)誤干細(xì)胞重建的血液系統(tǒng)引起了經(jīng)歷過輻射的人們的癌癥風(fēng)險(xiǎn)。
DeGregori說：“這是由自然選擇所驅(qū)動(dòng)的進(jìn)化。在健康血液系統(tǒng)中，健康干細(xì)胞會(huì)在競爭中勝過具有C/EBPα 突變的干細(xì)胞。但當(dāng)輻射降低干細(xì)胞群的健康和適應(yīng)性時(shí)，一直在那的突變細(xì)胞突然得到了接管的機(jī)會(huì)。”
從花栗鼠和松鼠的角度來思考這一問題：減少生物系統(tǒng)中的花栗鼠種群或許可使得松鼠興旺——尤其如果是減少花栗鼠的途經(jīng)改變了生態(tài)系統(tǒng)從而有利于松鼠，這與輻射改變機(jī)體來支持C/EBPα 突變干細(xì)胞相類似。

西班牙

想了解更多的產(chǎn)品及服務(wù)請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

【】 
【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Our body has evolved ways to get rid of defective stem cells. In a study published in the journal Stem Cells, researchers at the University of Colorado Cancer Center revealed that one of the ways to do this is through reprogramming to differentiate irradiated stem cells that no longer survive Other cells. Radiation can cause stem cells to lose their "dryness." This does make sense: You do not want damaged stem cells to stay there to create damaged cells.
The study also confirmed that the same "programmed" defense mechanism that cleared radiation-damaged stem cells when exposed to radiation throughout the body led to the growth of blood cancers (Extended reading: Sci Rep: abnormal blood flow in animals after Fukushima nuclear irradiation). By reprogramming this defense mechanism, we may be able to prevent cancer after systemic radiation.
"The body has not evolved to handle nuclear reactor leaks and CT scans," said senior author of the paper, Dr. James DeGregori, a professor of biochemistry and molecular genetics at the University of Colorado School of Medicine and a researcher at the Cancer Center. "It can only deal with a small number of patients receiving radiation exposure at a dangerous dose or The DNA was damaged by other cells. "
DeGregori, PhD candidate Courtney Fleenor and colleagues investigated the effects of whole body radiation on mouse hematopoietic stem cells (HSCs). In this case, radiation increases the chance of cell differentiation in the hematopoietic stem cell system. Only, although most cells follow this instruction, a few cells do not. Stem cells that carry a specific mutation are able to defy this differentiation and keep them "dry". Genetic inhibition of C / EBPα allows a small number of stem cells to maintain this capacity and continue to act as stem cells. In competition with other cells, healthy stem cells are cleared and stem cells with reduced C / EBPα dominate the hematopoietic system. In this way, the blood system changes from C / EBPα + cells to predominantly C / EBPα - cells.
Some mutations and other genetic variations that lead to the inhibition of the C / EBPα gene have been linked to human acute myeloid leukemia. Therefore, rather than the mutations caused by radiation, the blood system reconstructed by the wrong stem cells raises the cancer risk for those who have experienced radiation.
"This is evolution driven by natural selection," said DeGregori. "In a healthy blood system, healthy stem cells outperform stem cells with C / EBPα mutations in competition, but when radiation reduces the health and fitness of the stem cell population, Suddenly the mutant cells there got the chance to take over. "
Consider this from the chipmunk and squirrel perspectives: Reducing the population of chipmunk in the biological system may allow squirrels to thrive - especially if the path to the chipmunk is diminished by altering the ecosystem to benefit the squirrel, To support similar C / EBPα mutant stem cells.