西班牙Certest呼吸道合胞病毒單抗（克隆RV4）

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西班牙Certest呼吸道合胞病毒單抗（克隆RV4）

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3月3日科技部社會發(fā)展科技司也發(fā)表《國家重點研發(fā)計劃“大氣污染防治”重點專項實施方案(征求意見稿)》，其中提到要加強對污染源解析方法等研究。治理霧霾，控制大氣污染，要對PM2.5的具體組成成份進行分析，方可達到真正控制大氣污染的目的。
PM2.5中無機元素種類較多，鉛、鐵、鋅、鈣、鎘等有害金屬或類金屬元素常被檢出。不同金屬元素的濃度范圍相差很大，在數(shù)十甚至數(shù)百個ppm至ppt級的范圍內(nèi)，對儀器及檢測方法提出了較高要求。ICP-MS具有諸多優(yōu)點，是測定顆粒物中的無機元素技術(shù)的發(fā)展趨勢之一。環(huán)保標(biāo)準(zhǔn)HJ657-2013《空氣和廢氣顆粒物中鉛等金屬元素的測定-電感耦合等離子體質(zhì)譜法》便將ICP-MS檢測技術(shù)納入了法規(guī)。
zui近，來自美國斯克里普斯研究所(TSRI)、梅奧診所和其他機構(gòu)的一個研究小組，確定了一類新的藥物，可在動物模型中顯著減緩老化過程——緩解虛弱癥狀，改善心臟功能，延長健康壽命?？茖W(xué)家將這種新的藥物稱為“senolytics”。這一新的研究結(jié)果發(fā)表于三月九日出版的《Aging Cell》雜志。
TSRI教授Paul Robbins指出：“我們認(rèn)為，這項研究是開發(fā)延長健康壽命或與年齡有關(guān)疾病和障礙的治療方法(可安全地給予患者)的*步。當(dāng)我們所發(fā)現(xiàn)的senolytic進入臨床使用時，結(jié)果可能是變革性的。”
這項新研究的資深作者、梅奧診所的James Kirkland博士說：“研究證明，這些senolytic藥物的原型，不僅僅只是減輕衰老相關(guān)的多個特征。它zui終能夠可行地延遲、防止、減輕或逆轉(zhuǎn)多種慢性疾病和殘疾，而不是一次只針對一種情況。”
發(fā)現(xiàn)靶標(biāo)
衰老的細(xì)胞——已停止分裂的細(xì)胞，隨著年齡的增長而積累并加速老化過程。通過殺死這些細(xì)胞能夠延長小鼠的“健康壽命”(無疾病時間)，因此科學(xué)家們推斷，尋找能夠在人類中完成這一使命的治療方法，可能有著巨大的潛力。
但是，科學(xué)家們面臨的問題是，如何識別和靶定衰老細(xì)胞而不損害其他細(xì)胞。研究小組懷疑，衰老細(xì)胞對應(yīng)力和損傷所致死亡的抵抗力，可以提供一條線索。事實上，使用轉(zhuǎn)錄本分析，研究人員發(fā)現(xiàn)，如癌細(xì)胞一樣，衰老細(xì)胞的“促存活網(wǎng)絡(luò)”表達增加，可幫助它們抵抗細(xì)胞凋亡或程序性細(xì)胞死亡。這一發(fā)現(xiàn)為尋找潛在的候選藥物，提供了關(guān)鍵的標(biāo)準(zhǔn)。
使用這些標(biāo)準(zhǔn)，該研究小組把注意力集中在兩種可用的化合物——抗癌藥物達沙替尼(商品名Sprycel?)，和槲皮素——一種天然化合物作為補充劑出售，是一種抗組胺藥和消炎藥。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

March 3 Science and Technology Department of Social Development Science and Technology also released "key national R & D plan" air pollution prevention and control "key special implementation plan (draft)", which mentioned to strengthen the analysis of pollution sources and other research. To control smog and control air pollution, we should analyze the specific components of PM2.5 in order to achieve the purpose of real control of air pollution.
PM2.5 more inorganic elements, lead, iron, zinc, calcium, cadmium and other harmful metals or metalloid elements are often detected. The range of concentration of different metal elements is very different. In the range of tens or even hundreds of ppm to ppt, higher requirements are placed on the instruments and the detection methods. ICP-MS has many advantages and is one of the trends in the determination of inorganic elements in particulate matter. Environmental standards HJ657-2013 "Determination of lead and other metal elements in air and exhaust particulate matter - Inductively Coupled Plasma-Mass Spectrometry" ICP-MS detection technology into the law.
Recently, a team from the Scripps Research Institute (TSRI), Mayo Clinic and others set a new class of drugs that significantly slow the aging process in animal models - relieving weakness and improving the heart Function, extend healthy life expectancy. Scientists call this new drug "senolytics." This new study is published in the March 9 issue of Aging Cell magazine.
TSRI professor Paul Robbins said: "We believe this study is the first step toward developing a therapeutic approach to prolong healthy lifespan or age-related diseases and disorders that can be safely administered to patients." When we discovered that senolytic came into clinical use The result may be transformative. "
Dr James Kirkland, of the Mayo Clinic, a senior author of the new study, said: "Studies have shown that these prototypes of senolytic drugs do more than just reduce the multiple features associated with aging. It can eventually be feasibly delayed, prevented, mitigated, or reversed A variety of chronic illnesses and disability, not just one situation at a time. "
Find the target
Aging cells - cells that have stopped dividing, accumulate with age and accelerate the aging process. By killing these cells can extend the "healthy lifespan" of mice (disease-free time), scientists conclude that there may be great potential for finding a cure that can accomplish this mission in humans.
However, scientists are faced with the question of how to identify and target senescent cells without damaging other cells. The team suspects that the resistance of aging cells to stress and injury-induced death may provide a clue. In fact, using transcript analysis, the researchers found that, like cancer cells, the "pro-survival network" expression of senescent cells is increased, helping them to resist apoptosis or programmed cell death. This finding provides the key criteria for finding potential drug candidates.
Using these criteria, the team focused on the two available compounds, the anticancer drug dasatinib (trade name Sprycel®), and quercetin, a natural compound sold as a supplement, which is a Antihistamines and anti-inflammatory drugs.